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Gene Symbol IRS2
Synonyms IRS-2
Gene Description IRS2, insulin receptor substrate 2, is a member of the IRS family of intracellular adaptor proteins, which is involved in mediating IGF-IR signaling and functions in regulation of growth, metabolism (PMID: 17030631, PMID: 25200290), glucose uptake, cell migration, and cell invasion (PMID: 29669935). Overexpression and amplification of IRS2 are associated with colorectal cancer, breast cancer (PMID: 23594372, PMID: 23562473), and intrahepatic cholangiocarcinoma (PMID: 30250623) and gain of function mutations have been reported in pleomorphic invasive lobular breast carcinoma (PMID: 29669935).
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