Gene Detail

Gene Symbol IRS2
Synonyms IRS-2
Gene Description IRS2, insulin receptor substrate 2, is a member of the IRS family of intracellular adaptor proteins, which is involved in mediating IGF-IR signaling and functions in regulation of growth and metabolism (PMID: 17030631, PMID: 25200290). Over expression and amplification of IRS2 is associated with colorectal cancer and breast cancer (PMID: 23594372, PMID: 23562473).
Entrez Id 8660
Chromosome 13
Map Location 13q34
Canonical Transcript NM_003749

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