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|Synonyms||Cbl-b | Nbla00127 | RNF56|
|Gene Description||CBLB, Cbl proto-oncogene B, is an E3 ubiquitin ligase that negatively regulates receptor tyrosine kinase signaling through targeted degradation of active kinases, and is a key regulator of the immune system (PMID: 25477533, PMID: 30442330). CBLB mutations have been observed in myeloid neoplasms, and loss of CBLB in mouse models results in increased anti-tumor immunity (PMID: 19901108, PMID: 25477533).|