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Gene Symbol TNFRSF14
Synonyms ATAR | CD270 | HVEA | HVEM | LIGHTR | TR2
Gene Description TNFRSF14, TNF receptor superfamily member 14, encodes a transmembrane glycoprotein that acts as a receptor in the tumor necrosis factor signaling pathway, coordinating pro- and anti-inflammatory signaling, and plays a role in T-cell activation and maintenance (PMID: 22017438, PMID: 21920726). TNFRSF14 mutations have been identified in follicular lymphoma (PMID: 20884631) and diffuse large B-cell lymphoma (PMID: 22343534), and altered expression has been reported in multiple cancers including reduced levels in classical Hodgkin lymphoma (PMID: 26650888), and increased expression in gastric cancer (PMID: 28243127).
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