Gene Detail

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Gene Symbol

TRIM24

Synonyms

hTIF1 | PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA

Gene Description

TRIM24, tripartite motif containing 24, functions as E3 ubiquitin ligase that regulates Tp53 degradation, and also acts to regulate the transactivation activity of multiple nuclear receptors (PMID: 21979307, PMID: 19844164). TRIM24 fusions, with multiple fusion partners, have been identified in several cancer types, including including liver, thyroid (PMID: 24409330, PMID: 21979307), lung adenocarcinoma (PMID: 25204415), and melanoma (PMID: 24345920, PMID: 30254212), and Trim24 overexpression has been associated with more aggressive prostate cancer (PMID: 31178279).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
8805	7	7q33-q34	NM_015905	Both: Oncogene and Tumor suppressor (PMID: 30606230)