Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol HDAC3
Synonyms HD3 | KDAC3 | RPD3 | RPD3-2
Gene Description HDAC3, histone deacetylase 3, is a member of the class I HDAC family that functions in deacetylation of histone and non-histone proteins to repress transcription (PMID: 30472601, PMID: 30096875) and plays a role in inflammation (PMID: 29498635). Overexpression of Hdac3 has been observed in high-grade glioma (PMID: 30053564), in invasive ductal breast cancer (PMID: 29680858), in colorectal cancer (PMID: 29558042), and in classical Hodgkin lymphoma (PMID: 29481474).


Additional content available in CKB BOOST