Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||BETA-TRCP | betaTrCP | bTrCP | bTrCP1 | FBW1A | FBXW1 | FBXW1A | FWD1|
|Gene Description||BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase, is a member of the SKP1-CUL1-F-box complex that mediates ubiquitination and degradation of target proteins, and plays a role in regulating cell-cycle and signaling proteins (PMID: 30619291, PMID: 18285803). A fusion of BTRC with MGMT has been identified in glioma (PMID: 32753598), and overexpression of BTRC has been identified in colorectal cancer (PMID: 10882123, PMID: 15292388), and hepatoblastoma (PMID: 15958610).|