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Gene Symbol PAPSS1
Synonyms ATPSK1 | PAPSS | SK1
Gene Description PAPSS1, 3'-phosphoadenosine 5'-phosphosulfate synthase 1, encodes PAPS synthase 1, which is a bifunctional enzyme and universal sulfate donor (PMID: 26220590), that is necessary for sulfate reactions in eukaryotes (PMID: 22451673, PMID: 31131283). Overexpression of Papss1 has been observed in triple-negative breast cancer (PMID: 30146936) and a PAPSS1-BRAF fusion has been identified in melanoma (PMID: 24345920).
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