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Gene Symbol LATS1
Synonyms WARTS | wts
Gene Description LATS1, large tumor suppressor kinase 1, is a serine/threonine-protein kinase that negatively regulates YAP1 in the Hippo signaling pathway, which plays a role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PMID: 24026096). LATS1 may play a role as a tumor suppressor in human cancer (PMID: 24026096, PMID: 28644436).
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