Gene Detail
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| Gene Symbol | LATS1 | ||||||||||
| Synonyms | WARTS | wts | ||||||||||
| Gene Description | LATS1, large tumor suppressor kinase 1, is a serine/threonine-protein kinase that negatively regulates YAP1 in the Hippo signaling pathway, which plays a role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PMID: 24026096). LATS1 may play a role as a tumor suppressor in human cancer (PMID: 24026096, PMID: 28644436). | ||||||||||
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