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Gene Symbol SMC3
Synonyms BAM | BMH | CDLS3 | CSPG6 | HCAP | SMC3L1
Gene Description SMC3, structural maintenance of chromosomes 3, is a component of the cohesin complex, which functions in cohesion of sister chromatids during mitosis (PMID: 24856830, PMID: 23776448, PMID: 29187575). SMC3 mutations have been identified in chronic myeloid neoplasms (PMID: 30138727) as well as several additional hematological and solid tumor types (PMID: 24335498, PMID: 24856830, PMID: 23955599).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References