Gene Detail

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Gene Symbol

KLF4

Synonyms

EZF | GKLF

Gene Description

KLF4, Krueppel-like factor 4, is a transcription factor that regulates cell proliferation, metabolism, and maintenance of pluripotency (PMID: 31101597, PMID: 31141693) and acts as both an activator and repressor (PMID: 24551169). KLF4 expression has been associated with various tumor types (PMID: 25341045; PMID: 24551169; PMID: 23722653, PMID: 30540935) and may be oncogenic or a tumor suppressor, depending on the tumor type (PMID: 31101597), and KLF4 mutations have been observed in secretory meningiomas (PMID: 23404370).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
9314	9	9q31.2	NM_001314052	Both: Oncogene and Tumor suppressor (PMID: 30606230)