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Gene Symbol CD22
Synonyms SIGLEC-2 | SIGLEC2
Gene Description CD22, CD22 molecule, is a B-cell surface molecule that inhibits B-cell antigen receptor (BCR) signaling and therefore, induces tolerance to self-antigens (PMID: 24763061) and plays a role in autoimmunity (PMID: 30323814). CD22 is a target for cancer immunotherapies (PMID: 23696252) becausse of its predominant expression on the surface of B-cells in B-cell acute lymphoblastic leukemia (PMID: 32012891, PMID: 32245502, PMID: 32005917) and B cell lymphoma (PMID: 32232138).
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