Gene Detail


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Gene Symbol NHERF1
Synonyms EBP50 | NHE-RF | NHERF | NHERF-1 | NPHLOP2 | SLC9A3R1
Gene Description NHERF1, NHERF family PDZ scaffold protein 1, encodes a scaffold protein that links membrane-associated proteins with the actin cytoskeleton and is involved in regulation of cellular signaling, growth, migration, invasion, and autophagy (PMID: 26218645, PMID: 26788197, PMID: 31984791). NHERF1 mutations, decreased expression, or loss of cell membrane localization have been identified in several tumor types (PMID: 28068322), including, breast (PMID: 30326259), ovarian (PMID: 26788197), renal (PMID: 33965858), and colorectal cancers (PMID: 31867736).
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