Gene Detail
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| Gene Symbol | ABCG2 | ||||||||||
| Synonyms | ABC15 | ABCP | BCRP | BCRP1 | BMDP | CD338 | CDw338 | CDw388 | EST157481 | GOUT1 | MRX | MXR | MXR-1 | MXR1 | UAQTL1 | ||||||||||
| Gene Description | ABCG2, ATP binding cassette subfamily G member 2, is a member of the ABC transporter superfamily that is involved in efflux transport of various metabolites and xenobiotic substrates, and plays a role in cellular homeostasis (PMID: 22509477, PMID: 16305368). ABCG2 plays a role in multidrug resistance (PMID: 16305368, PMID: 22509477), and its expression has been identified in various solid tumors and hematologic cancers, including breast, lung, melanoma, acute myeloid leukemia, and acute lymphoblastic leukemia (PMID: 22509477), and overexpression in hepatocellular carcinoma (PMID: 27272814). | ||||||||||
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