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Gene Symbol CD47
Synonyms IAP | MER6 | OA3
Gene Description CD47, CD47 molecule, is an immunoglobulin superfamily protein that mediates cell-cell communication through binding to signal regulatory protein alpha (Sirpa) (PMID: 24627525) and servers as a marker of self recognition (PMID: 28286286). CD47 is often overexpressed on tumor cells to evade immune surveillance (PMID: 29743205) and therapeutic disruption of binding of CD47 to the Sirpa receptor on macrophages may stimulate phagocytosis of tumor cells (PMID: 28286286, PMID: 28258703).
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