Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||JHDM3A | JMJD2 | JMJD2A | TDRD14A|
|Gene Description||KDM4A, lysine demethylase 4A, is a Jumonji domain histone demethylase of H3K9 and H3K36, regulating gene transcription through chromatin remodeling to effect cell growth and differentiation (PMID: 24349617) and plays a role in hematopoietic stem cell maintenance (PMID: 31434704). KDM4A overexpression is commonly observed in ovarian cancer and in squamous cell carcinoma (PMID: 24349617, PMID: 29113308) and has also been implicated in prostatic intraepithelial tumors (PMID: 27767379).|