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Gene Symbol GPRIN2
Synonyms GRIN2 | KIAA0514
Gene Description GPRIN2, G protein regulated inducer of neurite outgrowth 2, interacts with activated alpha subunits of the Gi subfamily to induce neurite outgrowth in cell assays and is postulated to function downstream of G(o)alpha to regulate neurite growth (PMID: 10480904, PMID: 15488195). Mutations in Gprin2 have been observed in neuroblastoma (PMID: 29467591) and esophageal squamous cell carcinoma (PMID: 29405996).
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