Gene Detail
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| Gene Symbol | KEAP1 | ||||||||||
| Synonyms | INrf2 | KLHL19 | ||||||||||
| Gene Description | KEAP1, kelch like ECH associated protein 1, binds Nrf2 and targets it for ubiquitin-mediated degradation, thereby negatively regulating the downstream cytoprotective activity of Nrf2 (PMID: 24142871, PMID: 27263465, PMID: 28523248). KEAP1 loss-of-function mutations have been identified in several tumor types, including lung and liver cancers (PMID: 24142871, PMID: 27263465, PMID: 29615460). | ||||||||||
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