Gene Detail

Gene Symbol KEAP1
Synonyms INrf2 | KLHL19
Gene Description KEAP1, kelch like ECH-associated protein 1, binds Nrf2 and targets it for ubiquitin-mediated degradation, thereby negatively regulating the downstream cytoprotective activity of Nrf2 (PMID: 24142871, PMID: 27263465, PMID: 28523248). KEAP1 loss-of-function mutations have been identified in several tumor types, including lung and liver cancers (PMID: 24142871, PMID: 27263465).
Entrez Id 9817
Chromosome 19
Map Location 19p13.2
Canonical Transcript NM_203500


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