Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||ESET | H3-K9-HMTase4 | KG1T | KMT1E | TDRD21|
|Gene Description||SETDB1, SET domain bifurcated histone lysine methyltransferase 1, is a histone methyltransferase that regulates chromatin structure through methylation of H3K9 to repress gene transcription (PMID: 27732843, PMID: 28887438), and has a role in maintaining stem cell pluripotency (PMID: 19884255). Amplification of SETDB1 has been observed in a variety of cancers (PMID: 27732843), including lung (PMID: 23770855), breast (PMID: 25537518), and melanoma (PMID: 31131878).|