Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol MED12
Synonyms ARC240 | CAGH45 | FGS1 | HDKR | HOPA | Kto | MED12S | OHDOX | OKS | OPA1 | TNRC11 | TRAP230
Gene Description MED12, mediator complex subunit 12, is a subunit of Mediator, a complex involved in regulating expression of most RNA polymerase II transcripts (PMID: 24123922), and also regulates CDK8 activity (PMID: 31988137), Gli3-dependent Sonic hedgehog signaling, and epigenetic silencing of genes (PMID: 24123922). Mutations in Med12 have been identified in several cancers (PMID: 24123922, PMID: 31869450), including prostate cancer (PMID: 22610119), uterine leiomyoma (PMID: 32094355), and fibroepithelial tumors (PMID: 31662438).
Additional content available in CKB BOOST