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Gene | NRAS |
Variant | G13X |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | NRAS G13X indicates any NRAS missense mutation that results in replacement of the glycine (G) at amino acid 13 by a different amino acid. NRAS G13 mutations are hotspot mutations that often result in decreased Nras GTPase activity and transformation of cultured cells (PMID: 17517660, PMID: 26985062). |
Associated Drug Resistance | |
Category Variants Paths |
NRAS mutant NRAS exon2 NRAS G13X |
Transcript | NM_002524.5 |
gDNA | chr1:g.114716122_114716124 |
cDNA | c.37_39 |
Protein | p.G13 |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002524 | chr1:g.114716122_114716124 | c.37_39 | p.G13 | RefSeq | GRCh38/hg38 |
NM_002524.4 | chr1:g.114716122_114716124 | c.37_39 | p.G13 | RefSeq | GRCh38/hg38 |
NM_002524.5 | chr1:g.114716122_114716124 | c.37_39 | p.G13 | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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