Gene Variant Detail

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Gene STK11
Variant P281fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 P281fs likely results in a premature truncation of the Stk11 protein at amino acid 281 of 433 (UniProt.org). STK11 P281fs has not been characterized, however, due to the effects of truncation mutations downstream of P281 (PMID: 23612973), P281fs is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance

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Transcript NM_000455
gDNA chr19:g.1221320delC
cDNA c.842delC
Protein p.P281fs*6
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259617 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38
XM_005259618 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38
NM_000455 chr19:g.1221320delC c.842delC p.P281fs*6 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
STK11 P281fs loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References