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Gene APC
Variant C1410*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC C1410* results in a premature truncation of the Apc protein at amino acid 1410 of 2843 (UniProt.org). C1410* has not been characterized, however, due to the effects of other truncation mutations downstream of C1410 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC C1410*

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Transcript NM_000038.5
gDNA chr5:g.112839824C>A
cDNA c.4230C>A
Protein p.C1410*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.5 chr5:g.112839824C>A c.4230C>A p.C1410* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839824C>A c.4230C>A p.C1410* RefSeq GRCh38/hg38
NM_000038 chr5:g.112839824C>A c.4230C>A p.C1410* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839824C>A c.4230C>A p.C1410* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839824C>A c.4230C>A p.C1410* RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries