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|Gene Variant Descriptions||ABL1 Y253F lies within the protein kinase domain of the Abl1 protein (UniProt.org). Y253F has been demonstrated to occur as a secondary resistance mutation in the context of BCR-ABL (PMID: 18827185, PMID: 23044928), and results in increased kinase activity and enhanced cell proliferation in culture in the context of BCR-ABL in one study (PMID: 16880519), but in another study demonstrates reduced kinase activity in an in vitro assay (PMID: 33820471), and therefore, its effect on Abl1 protein function is unknown.|
|Associated Drug Resistance||Y|
|Category Variants Paths||
ABL1 mutant ABL1 Y253F
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|