Gene Variant Detail

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Gene FGFR1
Variant D165_D166del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FGFR1 D165_D166del (corresponds to D132_D133del in the canonical isoform) results in the deletion of two amino acids in the extracellular domain of the Fgfr1 protein from amino acids 165 to 166 (UniProt.org). D165_D166del has not been characterized in the scientific literature and therefore, its effect on Fgfr1 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 D165_D166del

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Transcript NM_001174067.2
gDNA chr8:g.38428395_38428400delGTCATC
cDNA c.493_498delGATGAC
Protein p.D165_D166delDD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716310.4 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38428021_38428026delACTGTC c.494_499delCAGTGA p.T165_V166delTV RefSeq GRCh38/hg38
XM_006716311.1 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
XM_011544450.3 chr8:g.38426196_38426201delTCAGAG c.493_498delTCTGAC p.S165_D166delSD RefSeq GRCh38/hg38
XM_047421573.1 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
XM_017013231.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
XM_017013219.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
NM_001174067.1 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166del RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38428021_38428026delACTGTC c.494_499delCAGTGA p.T165_V166delTV RefSeq GRCh38/hg38
NM_001354370.2 chr8:g.38424674_38424679delCAGGAT c.493_498delATCCTG p.I165_L166delIL RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_011544449.2 chr8:g.38426196_38426201delTCAGAG c.493_498delTCTGAC p.S165_D166delSD RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
XM_011544448.2 chr8:g.38426201_38426206delGGGCAC c.493_498delGTGCCC p.V165_P166delVP RefSeq GRCh38/hg38
XM_017013220.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_011544444.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_011544451.1 chr8:g.38424656_38424661delGGCGGG c.493_498delCCCGCC p.P165_A166delPA RefSeq GRCh38/hg38
XM_011544452.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
XM_006716312.2 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
NM_001354368.2 chr8:g.38424674_38424679delCAGGAT c.493_498delATCCTG p.I165_L166delIL RefSeq GRCh38/hg38
XM_006716314.3 chr8:g.38424674_38424679delCAGGAT c.493_498delATCCTG p.I165_L166delIL RefSeq GRCh38/hg38
XM_011544446.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
XM_047421574.1 chr8:g.38424674_38424679delCAGGAT c.493_498delATCCTG p.I165_L166delIL RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38428038_38428043delCACTGC c.493_498delGCAGTG p.A165_V166delAV RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
NM_001174067.2 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38
NM_023106.3 chr8:g.38424674_38424679delCAGGAT c.493_498delATCCTG p.I165_L166delIL RefSeq GRCh38/hg38
XM_017013227.2 chr8:g.38426196_38426201delTCAGAG c.493_498delTCTGAC p.S165_D166delSD RefSeq GRCh38/hg38
XM_017013226.2 chr8:g.38426201_38426206delGGGCAC c.493_498delGTGCCC p.V165_P166delVP RefSeq GRCh38/hg38
XM_047421572.1 chr8:g.38426196_38426201delTCAGAG c.493_498delTCTGAC p.S165_D166delSD RefSeq GRCh38/hg38
XM_047421576.1 chr8:g.38421936_38421941delAGCAGT c.493_498delACTGCT p.T165_A166delTA RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
NM_023105.3 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
NM_001174066.2 chr8:g.38424681_38424686delGGCCGG c.493_498delCGGCCC p.R165_P166delRP RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38428044_38428049delATGCAA c.493_498delTTGCAT p.L165_H166delLH RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38428395_38428400delGTCATC c.493_498delGATGAC p.D165_D166delDD RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References