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Gene TP53
Variant S241F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 S241F lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). S241F results in a decreased in Tp53 transcriptional activity (PMID: 19225112, PMID: 26585234), and interferes with formation of the Tp53/Bard1/CstF complex in cell culture (PMID: 21383700).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 S241F

TP53 mutant TP53 inact mut TP53 S241F

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Transcript NM_000546.5
gDNA chr17:g.7674241G>A
cDNA c.722C>T
Protein p.S241F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_000546 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674241G>A c.722C>T p.S241F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 S241F ovarian cancer sensitive Ganetespib Preclinical Actionable In a preclinical study, Ganetespib inhibited growth of human ovarian cancer cells harboring TP53 S241F in culture (PMID: 26009011). 26009011
TP53 S241F lung small cell carcinoma sensitive APR-246 Preclinical - Cell line xenograft Actionable In a preclinical study, APR-246 demonstrated efficacy in xenograft models of small cell lung cancer harboring TP53 S241F (PMID: 21415220). 21415220
TP53 S241F ovarian clear cell adenocarcinoma decreased response DS-7423 Preclinical - Cell culture Actionable In a preclinical study, an ovarian clear cell adenocarcinoma cell line harboring TP53 S241F demonstrated reduced sensitivity to DS-7423 in culture (PMID: 24504419). 24504419