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|Protein Effect||loss of function - predicted|
|Gene Variant Descriptions||ARID1A G1450fs results in a change in the amino acid sequence of the Arid1a protein beginning at aa 1450 of 2285, likely resulting in premature truncation of the functional protein (UniProt.org). G1450fs has not been characterized, however, due to the effects of truncation mutations downstream of G1450 (PMID: 26069190, PMID: 29736026), G1450fs is predicted to lead to a loss of Arid1a protein function.|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|