Gene Variant Detail

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Gene ATM
Variant G1459R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATM G1459R does not lie within any known functional domains of the Atm protein (UniProt.org). G1459R has been identified in sequencing studies (PMID: 26214590, PMID: 19781682), but has not been biochemically characterized and therefore, its effect on Atm protein function is unknown (PubMed, Aug 2022).
Associated Drug Resistance
Category Variants Paths

ATM mutant ATM G1459R

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Transcript NM_000051.3
gDNA chr11:g.108289740G>A
cDNA c.4375G>A
Protein p.G1459R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000051 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_005271562.5 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_005271561 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017790.2 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017790 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_011542843 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017791.1 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017789.2 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_011542843.2 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017792.2 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
NM_001351834.1 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_006718843 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017791 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_005271562 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_011542840 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_006718843.4 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
NM_000051.3 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_011542840.3 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017789 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38
XM_017017792 chr11:g.108289740G>A c.4375G>A p.G1459R RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References