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Gene DDR2
Variant R489fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions DDR2 R489fs results in a change in the amino acid sequence of the Ddr2 protein beginning at aa 489 of 855, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), R489fs is predicted to result in a loss of Ddr2 protein function.
Associated Drug Resistance

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Transcript NM_001014796
gDNA chr1:g.(162770472_162770473)
cDNA c.(1465_1464)
Protein p.R489fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001014796 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38
XM_006711344 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38
XM_011509588 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38
XM_011509586 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38
XM_011509587 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38
NM_006182 chr1:g.(162770472_162770473) c.(1465_1464) p.R489fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
DDR2 mutant lung squamous cell carcinoma sensitive Dasatinib Preclinical Actionable In a preclinical study, lung squamous cell cancer cells harboring DDR2 mutations demonstrated sensitivity to Sprycel (dasatinib) in culture (PMID: 22328973). 22328973
Molecular Profile Protein Effect Treatment Approaches
DDR2 R489fs loss of function - predicted