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|Protein Effect||no effect|
|Gene Variant Descriptions||RSPO3 over exp indicates an over expression of the Rspo3 protein. However, the mechanism causing the over expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RSPO3 over exp||cancer||not applicable||N/A||Preclinical - Pdx & cell culture||Emerging||In a preclinical study, advanced solid tumor cells overexpressing Rspo3 in culture and in patient-derived xenograft models demonstrated inhibition of beta-catenin activity and suppression of tumor growth when treated with RSPO3 specific antibodies, suggesting RSPO3 may be a promising therapeutic target (PMID: 26719531).||26719531|
|Molecular Profile||Protein Effect||Treatment Approaches|
|RSPO3 over exp||no effect|