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|Variant||ETV6 - PDGFRA|
|Protein Effect||gain of function - predicted|
|Gene Variant Descriptions||ETV6-PDGFRA results from the fusion of ETV6 and PDGFRA and is responsive to Pdgfra inhibition (PMID: 17555450), and therefore, is predicted to result in a gain of protein function. ETV6-PDGFRA has been identified in chronic eosinophilic leukemia (PMID: 24975316).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ETV6 - PDGFRA||chronic leukemia||predicted - sensitive||Imatinib||Case Reports/Case Series||Actionable||In a clinical case report, a patient with ETV6-PDGFRA positive chronic eosinophilic leukemia experienced complete cytogenic remission after treatment with Gleevec (imatinib) (PMID: 17555450).||17555450|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - PDGFRA||gain of function - predicted|