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|Protein Effect||no effect|
|Gene Variant Descriptions||ERBB2 (HER2) dec exp indicates decreased expression of the Erbb3 (Her3) protein and/or mRNA. However, the mechanism causing the decreased expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ERBB2 dec exp||breast cancer||predicted - sensitive||MP0274||Preclinical - Pdx||Actionable||In a preclinical study, MP0274 induced apoptosis in breast cancer cells with low level Erbb2 (Her2) expression in culture and inhibited tumor growth in patient-derived xenograft (PDX) models (Cancer Res 2013;73(24 Suppl): Abstract nr P4-12-30).||detail...|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ERBB2 dec exp||no effect|