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Gene | TP53 |
Variant | S241Y |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 S241Y lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). S241Y results in a loss of Tp53 transactivation activity and decreased ability to suppress colony formation in cell culture (PMID: 25584008). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 S241Y TP53 mutant TP53 inact mut TP53 S241Y |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674241G>T |
cDNA | c.722C>A |
Protein | p.S241Y |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |