Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene HRAS
Variant D33N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS D33N lies within the effector region of the Hras protein (UniProt.org). D33N demonstrates decreased binding affinity for effector protein Raf compared to wild-type Hras, and is not transforming in cell culture (PMID: 28686159, PMID: 8035810).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS D33N

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_005343.4
gDNA chr11:g.534226C>T
cDNA c.97G>A
Protein p.D33N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_005343 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_176795 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
HRAS D33N loss of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)