Gene Variant Detail

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Gene HRAS
Variant A59Rfs*32
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS A59Rfs*32 indicates a shift in the reading frame starting at amino acid 59 and terminating 32 residues downstream causing a premature truncation of the 189 amino acid Hras protein (UniProt.org). Due to the loss of the GTP binding domain (UniProt.org), A59Rfs*32 is predicted to lead to a loss of Hras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS A59Rfs*32

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Transcript NM_005343.4
gDNA chr11:g.533881_533882delCG
cDNA c.175_176delGC
Protein p.A59Rfs*32
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_005343 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References