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|Variant||ETV6 - FLT3|
|Protein Effect||gain of function|
|Gene Variant Descriptions||ETV6-FLT3 results from the fusion of ETV6 and FLT3, demonstrating the ability to transform cells in culture (PMID: 16761019) and has constitutively activated kinase activity (PMID: 19345670).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - FLT3||gain of function|