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Gene | ABL1 |
Variant | E281K |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ABL1 E281K lies within the protein kinase domain of the Abl1 protein (UniProt.org). E281K has been identified in the scientific literature (PMID: 21193419, PMID: 26603839, PMID: 33538150), but has not been biochemically characterized and therefore, its effect on Abl1 protein function is unknown (PubMed, Apr 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ABL1 mutant ABL1 E281K |
Transcript | NM_005157.6 |
gDNA | chr9:g.130872147G>A |
cDNA | c.841G>A |
Protein | p.E281K |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_005157.6 | chr9:g.130872147G>A | c.841G>A | p.E281K | RefSeq | GRCh38/hg38 |
NM_005157.5 | chr9:g.130872147G>A | c.841G>A | p.E281K | RefSeq | GRCh38/hg38 |
NM_005157 | chr9:g.130872147G>A | c.841G>A | p.E281K | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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