Gene Variant Detail

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Gene SMC3
Variant T586A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions SMC3 T586A lies within the SMC hinge region of the Smc3 protein (UniProt.org). T586A has been identified in sequencing studies (PMID: 23917401, PMID: 23797736), but has not been biochemically characterized and therefore, its effect on Smc3 protein function is unknown (PubMed, Mar 2020).
Associated Drug Resistance

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Transcript NM_005445
gDNA chr10:g.110591076A>G
cDNA c.1756A>G
Protein p.T586A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005445 chr10:g.110591076A>G c.1756A>G p.T586A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Protein Effect Treatment Approaches
SMC3 T586A unknown