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|Variant||ETV6 - PTPRR|
|Protein Effect||gain of function|
|Gene Variant Descriptions||ETV6-PTPRR (also referred to as TEL-PTPRR) results from the fusion of ETV6 and PTPRR, and leads to ligand-independent cell growth and Stat3 activation in culture (PMID: 16061641). ETV6-PTPRR has been identified in acute myelogenous leukemia (PMID: 16061641).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|ETV6 - PTPRR||gain of function|