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Gene PTEN
Variant H61D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN H61D lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H61D results in a loss of Pten phosphatase activity in yeast (PMID: 21828076, PMID: 17942903) and has high protein instability (PMID: 17942903).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN H61D

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Transcript NM_000314.6
gDNA chr10:g.87925529C>G
cDNA c.181C>G
Protein p.H61D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87925529C>G c.181C>G p.H61D RefSeq GRCh38/hg38
NM_000314 chr10:g.87925529C>G c.181C>G p.H61D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References