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Gene | FBXW7 |
Variant | G670fs |
Impact List | frameshift |
Protein Effect | unknown |
Gene Variant Descriptions | FBXW7 G670fs results in a change in the amino acid sequence of the Fbxw7 protein beginning at aa 670 of 707, likely resulting in premature truncation of the functional protein (UniProt.org). G670fs has been identified in sequencing studies (PMID: 26076459), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024). |
Associated Drug Resistance | |
Category Variants Paths |
FBXW7 mutant FBXW7 G670fs |
Transcript | NM_033632.3 |
gDNA | chr4:g.(152322997_152322998) |
cDNA | c.(2008_2007) |
Protein | p.G670fs |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011532085 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532083 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
NM_001349798.2 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_047415901.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_024454124.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_047415900.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_024454123.2 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
NM_033632.3 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532084.2 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_047415899.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532085.3 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532085.2 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532084.3 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_017008362 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_011532084 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_024454121.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
NM_033632.3 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_047415898.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_024454123.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_024454122.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
XM_047415897.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
NM_033632 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
NM_001349798.1 | chr4:g.(152322997_152322998) | c.(2008_2007) | p.G670fs | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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