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Gene FLT3
Variant V579A
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 V579A lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). V579A results in constitutive phosphorylation of Flt3, activation of Stat5 signaling, and is transforming in culture (PMID: 16410449).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 V579A

FLT3 mutant FLT3 exon14 FLT3 V579A

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Transcript NM_004119.2
gDNA chr13:g.28034183A>G
cDNA c.1736T>C
Protein p.V579A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28034183A>G c.1736T>C p.V579A RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28034183A>G c.1736T>C p.V579A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References