Gene Variant Detail

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Gene APC
Variant A1446_Q1447insDIA
Impact List insertion
Protein Effect unknown
Gene Variant Descriptions APC A1446_Q1447insDIA results in the insertion of three amino acids in the Apc protein between amino acids 1446 and 1447 (UniProt.org). A1446_Q1447insDIA has not been characterized in the scientific literature and therefore, its effect on Apc protein function is unknown (PubMed, Aug 2022).
Associated Drug Resistance
Category Variants Paths

APC mutant APC A1446_Q1447insDIA

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Transcript NM_000038.5
gDNA chr5:g.112839932_112839933insGACATCGCA
cDNA c.4338_4339insGACATCGCA
Protein p.A1446_Q1447insDIA
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112839932_112839933insGACATCGCA c.4338_4339insGACATCGCA p.A1446_Q1447insDIA RefSeq GRCh38/hg38
NM_000038 chr5:g.112839932_112839933insGACATCGCA c.4338_4339insGACATCGCA p.A1446_Q1447insDIA RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839932_112839933insGACATCGCA c.4338_4339insGACATCGCA p.A1446_Q1447insDIA RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839932_112839933insGACATCGCA c.4338_4339insGACATCGCA p.A1446_Q1447insDIA RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839932_112839933insGACATCGCA c.4338_4339insGACATCGCA p.A1446_Q1447insDIA RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References