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|Protein Effect||gain of function|
|Gene Variant Descriptions||RET act mut indicates that this variant results in a gain of function in the Ret protein. However the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RET act mut||lung non-small cell carcinoma||sensitive||Ponatinib||Preclinical - Cell culture||Actionable||In a preclinical study, Iclusig (ponatinib) inhibited RET phosphorylation and reduced viability of non-small cell lung cancer cells with RET activating mutations (Cancer Res April 15, 2013 73; 2084).||detail...|