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Gene FBXW7
Variant I347M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 I347M does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). I347M is predicted to have activity similar to wild-type Fbxw7 based on comparison and correlation analysis of induced gene expression signatures (PMID: 27147599), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 I347M

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Transcript NM_033632.3
gDNA chr4:g.152330813T>C
cDNA c.1041A>G
Protein p.I347M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532083 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532085 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
NM_033632 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_017008362 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_047415901.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532084 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152330813T>C c.1041A>G p.I347M RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References