Gene Variant Detail

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Gene FBXW7
Variant R658*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions FBXW7 R658* results in a premature truncation of the Fbxw7 protein at amino acid 658 of 707 (UniProt.org). R658* is associated with decreased Fbxw7 protein level in cell culture, but does not result in increased tumorigenesis compared to wild-type Fbxw7 in mouse models (PMID: 24838835), and therefore its effect on Fbxw7 protein function is unknown.
Associated Drug Resistance

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Transcript NM_033632.3
gDNA chr4:g.152323033G>A
cDNA c.1972C>T
Protein p.R658*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532083 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_017008362 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_011532084 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
NM_033632 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38
XM_011532085 chr4:g.152323033G>A c.1972C>T p.R658* RefSeq GRCh38/hg38

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 mutant Her2-receptor negative breast cancer predicted - sensitive LY3039478 Phase I Actionable In a Phase I trial, LY3039478 treatment resulted in partial response lasted 9.5 months in a patient with hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FBXW7 mutation (PMID: 30060061; NCT01695005). 30060061
Molecular Profile Protein Effect Treatment Approaches
FBXW7 R658* unknown