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|Variant||RUNX1 - MECOM|
|Protein Effect||gain of function|
|Gene Variant Descriptions||RUNX1-MECOM (also referred to as RUNX1-EVI1) results from the fusion of RUNX1 and MECOM, and leads to altered transcriptional regulation, transformation of hematopoietic cells in culture, and development of leukemia in animal models (PMID: 19016745). RUNX1-MECOM fusions are associated with myelodysplastic syndrome and myelogenous leukemia (PMID: 19016745).|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|
|RUNX1 - MECOM||gain of function|