Gene Variant Detail

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Gene FGFR2 OGA
Variant FGFR2 - OGA
Impact List fusion
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2-OGA results from the fusion of FGFR2 and OGA (PMID: 24550739), is associated with increased Fgfr2 expression and phosphorylation of Frs2 and Erk in patient tissue (PMID: 24550739), results in constitutive Fgfr2 phosphorylation in culture, but not does induce tumor growth in a mouse model (PMID: 33741397), and therefore, is predicted to lead to a gain of protein function. FGFR2-OGA has been identified in intrahepatic cholangiocarcinoma (PMID: 33741397).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 rearrange FGFR2 fusion FGFR2 - OGA

FGFR2 mutant FGFR2 act mut FGFR2 - OGA

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References