Gene Variant Detail

Gene FBXW7
Variant D550Mfs*6
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FBXW7 D550Mfs*6 indicates a shift in the reading frame starting at amino acid 550 and terminating 6 residues downstream causing a premature truncation of the 707 amino acid Fbxw7 protein (UniProt.org). D550Mfs*6 has not been characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, May 2018).
Associated Drug Resistance

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Transcript NM_033632
gDNA chr4:g.152324391delC
cDNA c.1648delG
Protein p.D550Mfs*6
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011532083 chr4:g.152324391delC c.1648delG p.D550Mfs*6 RefSeq GRCh38/hg38
XM_011532085 chr4:g.152324391delC c.1648delG p.D550Mfs*6 RefSeq GRCh38/hg38
XM_017008362 chr4:g.152324391delC c.1648delG p.D550Mfs*6 RefSeq GRCh38/hg38
XM_011532084 chr4:g.152324391delC c.1648delG p.D550Mfs*6 RefSeq GRCh38/hg38
NM_033632 chr4:g.152324391delC c.1648delG p.D550Mfs*6 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FBXW7 D550Mfs*6 unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References