Gene Variant Detail

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Gene HRAS
Variant G13D
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G13D is hotspot mutation that lies within the GTP nucleotide binding region of the Hras protein (UniProt.org). G13D results in decreased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to activation of downstream signaling and senescence in cell culture (PMID: 24224811, PMID: 21850009).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13D

HRAS mutant HRAS G13X HRAS G13D

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Transcript NM_005343.4
gDNA chr11:g.534285C>T
cDNA c.38G>A
Protein p.G13D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.4 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_001130442 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_005343 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38
NM_176795 chr11:g.534285C>T c.38G>A p.G13D RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References