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Gene | FLT3 |
Variant | G282R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 G282R lies within the Ig-like C2-type domain of the Flt3 protein (UniProt.org). G282R has been identified in sequencing studies (PMID: 24728327), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2023). |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 G282R |
Transcript | NM_004119.3 |
gDNA | chr13:g.28049673C>T |
cDNA | c.844G>A |
Protein | p.G282R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.3 | chr13:g.28049673C>T | c.844G>A | p.G282R | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28049673C>T | c.844G>A | p.G282R | RefSeq | GRCh38/hg38 |
NM_004119.2 | chr13:g.28049673C>T | c.844G>A | p.G282R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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